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Broadly, GLP-1 RAs activate neural signaling from the hypothalamus, resulting in increased secretion of neuropeptides, such as the gonadotropin releasing hormone, and various downstream effects on the hypothalamic-pituitary axis

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1 H NMR (400 MHz, DMSO- d 6 ) was shown in Supplementary Fig

Additionally, rapid weight loss in older adults can lead to loss of lean muscle mass (sarcopenia), which may impact functional status and increase fall risk